Appropriate analysis frameworks, which are based upon Aboriginal and Torres Strait Islander worldviews and understandings, are required to gain a greater understanding of Aboriginal and Torres Strait Islander health and health issues in a culturally safe way. In this paper, the example of Aboriginal and Torres Strait Islander suicide is used to explore the development of such an analysis framework. A deeper understanding of the links between social and environmental determinants of suicide and cultural determinants of health is required to address the gap in suicide rates between Indigenous and non-Indigenous people in Australia. A qualitative analysis framework which identifies factors unique to Aboriginal and Torres Strait Islander suicide will be developed using a staged process. First, a realist literature review will be conducted and a draft framework will be developed. Key areas which will be reviewed for inclusion in the framework include cultural factors, family factors, trauma, major life events, involvement in sport and/ or art and experiences of discrimination. Second, a collaborative inquiry approach will be used to present the framework to stakeholders at a workshop. Feedback will be received from participants at the workshop to ensure that relevant items, including psychological, social and cultural factors, are adequately covered. Stakeholders will include Aboriginal and non-Aboriginal participants from a range of key community controlled and government organisations. The process used to develop the analysis framework and the analysis framework itself will be presented. This will demonstrate a process that can be used by other researchers to create analysis frameworks for other health issues that are based upon Aboriginal and Torres Strait Islander worldviews and understandings. This is important in developing further scholarship and conversation about Aboriginal and Torres Strait Islander analyses of health and health issues.